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ZMapp Adlı İlaç Ebola’ya Yakalanan İki Liberyalı Doktorda Denenecek

Ebola outbreak: Liberia says experimental drug on the way from US

Liberian government says ZMapp will be given to two infected doctors, while US manufacturer says supply has now run out

Associated Press in Monrovia

Tuesday 12 August 2014 10.56 BST

Liberia has announced it is to receive doses of an experimental Ebola drug and give it to two sick doctors, making them the first Africans to receive some of the scarce treatment in a spiralling outbreak.

The US government confirmed that it had put Liberian officials in touch with the maker of ZMapp and referred additional questions to the manufacturer. In a statement, the California-based Mapp Biopharmaceutical said that in responding to a request from an unidentified west African country it had run out of its supply of the treatment.

The news came amid growing anger over the fact that the only people to receive the experimental treatment so far had been westerners: two Americans and a Spaniard, all of whom were evacuated to their home countries from Liberia.

On Monday the World Health Organisation said 1,013 people had died in the Ebola outbreak in west Africa. Authorities had recorded 1,848 suspected, probable or confirmed cases of the disease, the UN health agency said. The updated WHO tally includes figures from 7-9 August when 52 more people died and 69 more were infected.

There is no Ebola vaccine or treatment available but there are several in development besides ZMapp. That treatment is so new that it has not been tested for safety or effectiveness in humans. The company has said it would take months to produce even modest quantities.

It was unclear how much of the treatment would be sent to Liberia.

The Liberian statement, posted on the presidency’s website, said it was also receiving an experimental treatment from the World Health Organisation. It was unclear if this was referring to ZMapp or another treatment.

In the past few weeks the experimental drug was given to two American aid workers diagnosed with the disease while working at a hospital that treated Ebola patients. On Monday officials in Spain disclosed that the treatment was also given to a Spanish missionary priest who fell ill while working in Liberia.

The Americans are said to be improving but there was no way to know whether the drug helped or if they are getting better on their own. Around 40% of those infected with Ebola are surviving the current outbreak.

Some have called for the untested drug to be given to Africans. The outbreak was first identified in March in Guinea but likely started months earlier. It has since spread to neighbouring Liberia and Sierra Leone, and possibly to Nigeria.

The ethical dilemmas over using an untested drug and who should get it prompted the UN health agency to consult on Monday with ethicists, infectious disease experts, patient representatives and the Doctors Without Borders group. Most participants in the closed teleconference were from developed countries but Uganda and Senegal were represented. The World Health Organisation said it would discuss the results of the meeting at a press conference on Tuesday.

Companies can provide experimental drugs on a “compassionate use” basis, usually after they have been fully tested in humans. The Food and Drug Administration approves such uses in the US but has no authority overseas. Ultimately the companies alone decide whether or not to share their products.

Spain’s health ministry said it obtained ZMapp this weekend with company permission to treat Miguel Pajares, a 75-year-old priest evacuated from Liberia and placed in isolation on Thursday at Madrid’s Carlos III hospital.

“The medicine was imported from Geneva where there was one dose available in the context of an accord between the laboratory that developed the medicine, WHO and [Doctors Without Borders],” the ministry said, invoking a Spanish law permitting unauthorised medication for patients with life-threatening illnesses.

Spanish authorities refused to comment beyond the ministry’s statement but Geneva University hospital told the Associated Press it was involved in getting the drug to Madrid.

The evacuated American aid workers, Dr Kent Brantly and Nancy Writebol, have been improving at Atlanta’s Emory University hospital. They got the treatment after their international relief group Samaritan’s Purse asked Kentucky BioProcessing, which produces it for Mapp Biopharmaceutical.

The treatment mixes three antibodies engineered to recognise Ebola and bind to infected cells so the immune system can kill them.

A Sierra Leone official said they had not asked for the drug but the other governments said they wanted any treatment that might help patients recover, despite the risks of unproven medicines. “The alternative for not testing this is death, a certain death,” said Liberia’s information minister, Lewis Brown.

Alhoussein Makanera Kake, a spokesman for the Guinean government committee on Ebola, said: “Guinean authorities would naturally be interested in having this medicine.”

In other Ebola developments on Monday an African nun who worked with the infected Spanish priest died from Ebola in Liberia, their Catholic aid group said.

A nurse who treated Patrick Sawyer also died, Nigerian authorities said. She had treated the Liberian-American when he flew into Nigeria and died last month. The nurses’s death raised the number of locally confirmed Ebola cases to 10. Nigeria is monitoring 177 contacts of Sawyer to contain the outbreak. The WHO has yet to confirm any Ebola cases in Nigeria.

Ivory Coast, which shares borders with Liberia and Guinea, has banned direct flights from the infected countries and said it would increase health inspections and enforcement of its borders, but stopped short of closing them entirely.

George Weah, a Liberian former Fifa world player of the year, joined awareness efforts by recording a song titled Ebola Is Real, with proceeds going to the Liberian health ministry.