{"id":6257,"date":"2023-10-04T15:12:54","date_gmt":"2023-10-04T12:12:54","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=6257"},"modified":"2023-10-06T15:14:03","modified_gmt":"2023-10-06T12:14:03","slug":"mrna-teknolojisi-kanser-ve-diger-hastaliklara-karsi-bagisiklik-kazandirabilir-mi","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/mrna-teknolojisi-kanser-ve-diger-hastaliklara-karsi-bagisiklik-kazandirabilir-mi\/","title":{"rendered":"mRNA Teknolojisi Kanser ve Di\u011fer Hastal\u0131klara Kar\u015f\u0131 Ba\u011f\u0131\u015f\u0131kl\u0131k Kazand\u0131rabilir mi?"},"content":{"rendered":"
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\"\"<\/b>Yak\u0131n zamana kadar \u00e7o\u011fu insan mRNA a\u015f\u0131lar\u0131n\u0131n ad\u0131n\u0131 bile duymam\u0131\u015ft\u0131. \u015eimdi ise bilim insanlar\u0131 bu a\u015f\u0131lar\u0131n dayand\u0131\u011f\u0131 ve Nobel \u00d6d\u00fcl\u00fc alan teknolojinin pek \u00e7ok sa\u011fl\u0131k sorununu \u00e7\u00f6zmede kilit rol oynayabilece\u011fine inan\u0131yor.<\/strong><\/p>\n<\/div>\n

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\u00dc\u00e7 y\u0131l kadar \u00f6nce Anna Blakney, Londra’daki bir laboratuvarda yeni bir alanda \u00e7al\u0131\u015f\u0131rken bilim \u00e7evresi d\u0131\u015f\u0131nda \u00e7ok az insan mRNA a\u015f\u0131lar\u0131n\u0131 duymu\u015ftu.<\/p>\n<\/div>\n

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Covid-19 salg\u0131n\u0131 nedeniyle art\u0131k pek \u00e7ok insan Pfizer-BioNTech ve Moderna gibi ila\u00e7 \u015firketlerinin mRNA a\u015f\u0131lar\u0131ndan haberdar. Ancak \u00fc\u00e7 y\u0131l kadar \u00f6nce Anna Blakney, Londra’daki bir laboratuvarda nispeten g\u00f6ze \u00e7arpmayan, ni\u015f bir bilim alan\u0131nda \u00e7al\u0131\u015f\u0131yordu. Bilim \u00e7evresi d\u0131\u015f\u0131nda \u00e7ok az insan mRNA a\u015f\u0131lar\u0131n\u0131 duymu\u015ftu<\/p>\n<\/div>\n

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Blakney 2016’da Londra’daki Imperial College’da doktoras\u0131na ba\u015flad\u0131\u011f\u0131nda bile, “pek \u00e7ok insan bunun i\u015fe yaray\u0131p yaramayaca\u011f\u0131 konusunda \u015f\u00fcpheciydi”. \u015eimdiyse “mRNA’n\u0131n t\u0131pta oyunun kurallar\u0131n\u0131 de\u011fi\u015ftiriyor” diyor.<\/p>\n

Haberci ribon\u00fckleik asit ya da k\u0131saca mRNA \u00e7ok b\u00fcy\u00fck, heyecan verici sorular\u0131 g\u00fcndeme getiriyor: mRNA a\u015f\u0131lar\u0131 kanser, HIV, tropikal hastal\u0131klar i\u00e7in bir tedavi sa\u011flayabilir ve hatta bize insan\u00fcst\u00fc bir ba\u011f\u0131\u015f\u0131kl\u0131k kazand\u0131rabilir mi?<\/p>\n

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mRNA, genetik kodu DNA’dan h\u00fccrenin protein yapma mekanizmas\u0131na ta\u015f\u0131yan tek sarmall\u0131 bir molek\u00fcl. mRNA olmadan genetik kodunuz kullan\u0131lamaz, proteinler yap\u0131lamaz ve v\u00fccudunuz \u00e7al\u0131\u015famaz. E\u011fer DNA banka kart\u0131 ise, mRNA da kart okuyucudur.<\/p>\n<\/div>\n

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Bir vir\u00fcs h\u00fccrelerimize girdi\u011finde, kendi RNA’s\u0131n\u0131 serbest b\u0131rak\u0131r ve ele ge\u00e7irilmi\u015f h\u00fccrelerimizi kand\u0131rarak ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi tehlikeye atacak \u015fekilde vir\u00fcs\u00fcn kopyalar\u0131n\u0131 – viral proteinler \u015feklinde – d\u0131\u015far\u0131 atar.<\/p>\n<\/div>\n

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Geleneksel a\u015f\u0131lar, antijen ad\u0131 verilen zay\u0131flat\u0131lm\u0131\u015f vir\u00fcs proteinlerinin enjekte edilmesiyle \u00e7al\u0131\u015f\u0131r ve bu da v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sistemini vir\u00fcs\u00fc yeniden ortaya \u00e7\u0131kt\u0131\u011f\u0131nda tan\u0131mas\u0131 i\u00e7in uyar\u0131r.<\/p>\n<\/div>\n

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MRNA a\u015f\u0131lar\u0131nda ise antijenin kendisini enjekte etmeye gerek yoktur. Bunun yerine, bu a\u015f\u0131lar antijenin mRNA’ya \u00e7evrilmi\u015f genetik dizisini veya “kodunu” kullan\u0131r. Bu, ger\u00e7e\u011finin hayaleti gibidir ve v\u00fccudu kand\u0131rarak ger\u00e7ek antikorlar olu\u015fturmas\u0131n\u0131 sa\u011flar. Daha sonra yapay mRNA’n\u0131n kendisi, onu par\u00e7alayan enzimler de dahil olmak \u00fczere v\u00fccudun do\u011fal savunmas\u0131 taraf\u0131ndan bozularak yok olur ve bize sadece antikorlar kal\u0131r.<\/p>\n<\/div>\n

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Bu nedenle mRNA a\u015f\u0131lar\u0131 geleneksel a\u015f\u0131lara k\u0131yasla daha g\u00fcvenli, daha h\u0131zl\u0131 ve daha ucuza \u00fcretilebilir. Art\u0131k milyonlarca tavuk yumurtas\u0131n\u0131n i\u00e7inde \u00f6l\u00fcmc\u00fcl vir\u00fcsler yeti\u015ftiren devasa biyo-g\u00fcvenlikli laboratuvarlara ihtiya\u00e7 yok. Bunun yerine, tek bir laboratuvar antijenin proteinlerini liste halinde t\u00fcm d\u00fcnyaya e-posta ile g\u00f6nderebilir.<\/p>\n

Yaz\u0131n\u0131n Devam\u0131 \u0130\u00e7in T\u0131klay\u0131n\u0131z<\/strong><\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Yak\u0131n zamana kadar \u00e7o\u011fu insan mRNA a\u015f\u0131lar\u0131n\u0131n ad\u0131n\u0131 bile duymam\u0131\u015ft\u0131. \u015eimdi ise bilim insanlar\u0131 bu a\u015f\u0131lar\u0131n dayand\u0131\u011f\u0131 ve Nobel \u00d6d\u00fcl\u00fc alan teknolojinin pek \u00e7ok sa\u011fl\u0131k sorununu \u00e7\u00f6zmede kilit rol oynayabilece\u011fine inan\u0131yor. \u00dc\u00e7 y\u0131l kadar \u00f6nce Anna Blakney, Londra’daki bir laboratuvarda yeni bir alanda \u00e7al\u0131\u015f\u0131rken bilim \u00e7evresi d\u0131\u015f\u0131nda \u00e7ok az insan mRNA a\u015f\u0131lar\u0131n\u0131 duymu\u015ftu. Covid-19 salg\u0131n\u0131 nedeniyle art\u0131k pek \u00e7ok insan Pfizer-BioNTech ve Moderna gibi ila\u00e7 \u015firketlerinin mRNA a\u015f\u0131lar\u0131ndan haberdar. Ancak \u00fc\u00e7 y\u0131l kadar \u00f6nce Anna Blakney, Londra’daki bir laboratuvarda nispeten g\u00f6ze \u00e7arpmayan, ni\u015f bir bilim alan\u0131nda \u00e7al\u0131\u015f\u0131yordu. Bilim \u00e7evresi d\u0131\u015f\u0131nda \u00e7ok az insan mRNA a\u015f\u0131lar\u0131n\u0131 duymu\u015ftu Blakney 2016’da Londra’daki Imperial […]<\/p>\n","protected":false},"author":4,"featured_media":6258,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6257"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=6257"}],"version-history":[{"count":1,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6257\/revisions"}],"predecessor-version":[{"id":6259,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6257\/revisions\/6259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/6258"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=6257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=6257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=6257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}