{"id":6250,"date":"2023-10-04T15:08:52","date_gmt":"2023-10-04T12:08:52","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=6250"},"modified":"2023-10-04T15:09:27","modified_gmt":"2023-10-04T12:09:27","slug":"mrna-covid-asilari-hayat-kurtardi-ve-nobel-kazandi-mrna-teknolojisi-icin-sirada-ne-var","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/mrna-covid-asilari-hayat-kurtardi-ve-nobel-kazandi-mrna-teknolojisi-icin-sirada-ne-var\/","title":{"rendered":"mRNA COVID A\u015f\u0131lar\u0131 Hayat Kurtard\u0131 ve Nobel Kazand\u0131; mRNA Teknolojisi \u0130\u00e7in S\u0131rada Ne Var?"},"content":{"rendered":"

\"\"Sadece \u00fc\u00e7 y\u0131l gibi k\u0131sa bir s\u00fcrede mRNA a\u015f\u0131lar\u0131 milyonlarca hayat kurtard\u0131; herkes taraf\u0131ndan tan\u0131nd\u0131 ve bu hafta itibariyle Nobel \u00d6d\u00fcl\u00fc’ne konu oldu. Alandaki \u00e7al\u0131\u015fmalar ise h\u0131z kesmeden devam ediyor gibi g\u00f6r\u00fcn\u00fcyor.<\/strong><\/p>\n

mRNA teknolojisinin COVID-19 a\u015f\u0131lar\u0131 \u00fcretmedeki h\u0131zl\u0131 manevras\u0131yla kazand\u0131\u011f\u0131 \u00e7arp\u0131c\u0131 ba\u015far\u0131n\u0131n ard\u0131ndan yat\u0131r\u0131mc\u0131lar mRNA’n\u0131n terap\u00f6tik alan\u0131n\u0131 geni\u015fletmek i\u00e7in milyarlarca dolar d\u00f6kt\u00fc.<\/p>\n

Bu nakit ak\u0131\u015f\u0131n\u0131n, tedavisi zor bula\u015f\u0131c\u0131 hastal\u0131klar, kanserler ve nadir g\u00f6r\u00fclen genetik bozukluklarla m\u00fccadelede mRNA ila\u00e7lar\u0131n\u0131n halk sa\u011fl\u0131\u011f\u0131n\u0131 d\u00f6n\u00fc\u015ft\u00fcrebilecek \u015fekilde kullan\u0131lmas\u0131 i\u00e7in gereken ara\u015ft\u0131rmalara ve altyap\u0131ya yak\u0131t olmas\u0131 umut ediliyor.<\/p>\n

Seattle, Washington’daki Fred Hutchinson Kanser Ara\u015ft\u0131rma Merkezi’nden imm\u00fcnolog Matthias Stephan, “S\u0131n\u0131r g\u00f6ky\u00fcz\u00fcd\u00fcr” diyor. “D\u00fczeltmek veya tedavi etmek istedi\u011finiz her \u015fey i\u00e7in bir mRNA ilac\u0131 olabilir; heyecan bu y\u00fczden.”<\/p>\n

Nature, ufuktaki mRNA ila\u00e7lar\u0131 hakk\u0131nda ara\u015ft\u0131rmac\u0131larla konu\u015ftu.<\/p>\n

Salg\u0131nlar\u0131 kontrol alt\u0131na almak: H\u0131z\u0131n \u00f6nemli oldu\u011fu durumlarda<\/strong><\/p>\n

mRNA’ya dayanan a\u015f\u0131lar, yaln\u0131zca g\u00fcvenlikleri ve etkinlikleriyle de\u011fil, ayn\u0131 zamanda COVID-19 salg\u0131n\u0131 s\u0131ras\u0131nda geli\u015ftirilme ve piyasaya s\u00fcr\u00fclme h\u0131zlar\u0131yla da \u00fcn kazand\u0131.<\/p>\n

ABD Ulusal Sa\u011fl\u0131k Enstit\u00fcleri’nde mRNA tabanl\u0131 COVID-19 a\u015f\u0131lar\u0131ndan birinin geli\u015ftirilmesine katk\u0131 sunan Barney Graham, bu yakla\u015f\u0131m\u0131n ara\u015ft\u0131rmac\u0131lar\u0131n “\u00e7ok etkili bir a\u015f\u0131y\u0131 birka\u00e7 hafta i\u00e7inde kullan\u0131ma sunmas\u0131na” olanak tan\u0131d\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. (Graham \u015fu anda Atlanta, Georgia’daki Morehouse T\u0131p Fak\u00fcltesi’nde k\u00fcresel sa\u011fl\u0131k e\u015fitli\u011fi konusunda k\u0131demli dan\u0131\u015fman olarak g\u00f6rev yap\u0131yor.)<\/p>\n

A\u015f\u0131lar, ki\u015finin h\u00fccrelerine antijen olarak da bilinen viral proteinin kopyalar\u0131n\u0131 olu\u015fturma talimat\u0131 veren mRNA’y\u0131 sa\u011flarlar. Bu s\u00fcre\u00e7 v\u00fccudu koruyucu antikorlar ve virusla sava\u015fan ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri \u00fcretmeye te\u015fvik eder.<\/p>\n

Sentetik mRNA birka\u00e7 g\u00fcn i\u00e7inde tasarlan\u0131p \u00fcretilebildi\u011fi i\u00e7in teknoloji her y\u0131l SARS-CoV-2 ve grip gibi\u00a0 s\u00fcrekli de\u011fi\u015fen viruslara y\u00f6nelik a\u015f\u0131lar\u0131n h\u0131zl\u0131 bir \u015fekilde yeniden form\u00fcle edilmesine imkan veriyor. Veya yeni bula\u015f\u0131c\u0131 tehditler kar\u015f\u0131s\u0131nda h\u0131zl\u0131 yan\u0131t arac\u0131 olarak kullan\u0131labilir. \u00d6rne\u011fin, Cambridge, Massachusetts’te bir biyoteknoloji \u015firketi olan Moderna, maymun \u00e7i\u00e7e\u011fi, Zika ve Nipah vir\u00fcslerine kar\u015f\u0131 mRNA a\u015f\u0131lar\u0131n\u0131 denedi.<\/p>\n

Bu y\u0131l\u0131n Nobel \u00d6d\u00fcl\u00fc sahipleri Philedelphia’daki Pennsylvania \u00dcniversitesi’nden (UPenn) imm\u00fcnolog Drew Weissman ve Macaristan’daki Szeged \u00dcniversitesi’nden biyokimyac\u0131 Katalin Karik\u00f3 ile yak\u0131n \u00e7al\u0131\u015fan ve kendisi de UPenn’den olan a\u015f\u0131 bilimci Norbert Pardi, “mRNA a\u015f\u0131s\u0131 \u00fcretiminin esnekli\u011finden ve basitli\u011finden kesinlikle yararlanabiliriz” diyor. \u00d6d\u00fcl sahibi bu iki ki\u015fi 2000’li y\u0131llar\u0131n ortalar\u0131nda mRNA a\u015f\u0131lar\u0131n\u0131n olu\u015fturulmas\u0131nda kullan\u0131lan baz\u0131 temel teknolojileri geli\u015ftirdi.<\/p>\n

Haber \u0130\u00e7in T\u0131klay\u0131n\u0131z<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Sadece \u00fc\u00e7 y\u0131l gibi k\u0131sa bir s\u00fcrede mRNA a\u015f\u0131lar\u0131 milyonlarca hayat kurtard\u0131; herkes taraf\u0131ndan tan\u0131nd\u0131 ve bu hafta itibariyle Nobel \u00d6d\u00fcl\u00fc’ne konu oldu. Alandaki \u00e7al\u0131\u015fmalar ise h\u0131z kesmeden devam ediyor gibi g\u00f6r\u00fcn\u00fcyor. mRNA teknolojisinin COVID-19 a\u015f\u0131lar\u0131 \u00fcretmedeki h\u0131zl\u0131 manevras\u0131yla kazand\u0131\u011f\u0131 \u00e7arp\u0131c\u0131 ba\u015far\u0131n\u0131n ard\u0131ndan yat\u0131r\u0131mc\u0131lar mRNA’n\u0131n terap\u00f6tik alan\u0131n\u0131 geni\u015fletmek i\u00e7in milyarlarca dolar d\u00f6kt\u00fc. Bu nakit ak\u0131\u015f\u0131n\u0131n, tedavisi zor bula\u015f\u0131c\u0131 hastal\u0131klar, kanserler ve nadir g\u00f6r\u00fclen genetik bozukluklarla m\u00fccadelede mRNA ila\u00e7lar\u0131n\u0131n halk sa\u011fl\u0131\u011f\u0131n\u0131 d\u00f6n\u00fc\u015ft\u00fcrebilecek \u015fekilde kullan\u0131lmas\u0131 i\u00e7in gereken ara\u015ft\u0131rmalara ve altyap\u0131ya yak\u0131t olmas\u0131 umut ediliyor. Seattle, Washington’daki Fred Hutchinson Kanser Ara\u015ft\u0131rma Merkezi’nden imm\u00fcnolog Matthias Stephan, “S\u0131n\u0131r g\u00f6ky\u00fcz\u00fcd\u00fcr” diyor. “D\u00fczeltmek veya tedavi etmek istedi\u011finiz […]<\/p>\n","protected":false},"author":4,"featured_media":6251,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6250"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=6250"}],"version-history":[{"count":2,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6250\/revisions"}],"predecessor-version":[{"id":6253,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6250\/revisions\/6253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/6251"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=6250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=6250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=6250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}