{"id":6030,"date":"2022-09-24T12:37:10","date_gmt":"2022-09-24T09:37:10","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=6030"},"modified":"2022-10-04T13:29:44","modified_gmt":"2022-10-04T10:29:44","slug":"kubanin-covid-19a-karsi-gelistirdigi-abdala-asisinin-etkililigine-iliskin-gercek-yasam-verileri-the-lancet-dergisinde-yayimlandi","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/kubanin-covid-19a-karsi-gelistirdigi-abdala-asisinin-etkililigine-iliskin-gercek-yasam-verileri-the-lancet-dergisinde-yayimlandi\/","title":{"rendered":"K\u00fcba’n\u0131n COVID-19’a Kar\u015f\u0131 Geli\u015ftirdi\u011fi Abdala A\u015f\u0131s\u0131n\u0131n Etkilili\u011fine \u0130li\u015fkin Ger\u00e7ek Ya\u015fam Verileri The Lancet Dergisinde Yay\u0131mland\u0131"},"content":{"rendered":"

\"\"K\u00fcba’n\u0131n pandemi s\u0131ras\u0131nda geli\u015ftirdi\u011fi Abdala a\u015f\u0131s\u0131n\u0131n COVID-19’dan kaynaklanan ciddi hastal\u0131klar\u0131 ve \u00f6l\u00fcmleri \u00f6nlemede y\u00fcksek etkiye sahip oldu\u011funu g\u00f6steren \u00e7al\u0131\u015fma 24 Eyl\u00fcl 2022’de The Lancet dergisinde yay\u0131mland\u0131.<\/strong><\/p>\n

K\u00fcba protein alt birim a\u015f\u0131s\u0131 Abdala’n\u0131n, SARS-CoV-2’ye kar\u015f\u0131 g\u00fcvenli\u011fi, tolere edilebilirli\u011fi ve etkilili\u011fi (%92 3 [%95 GA: 85 7-95 8]) klinik deneylerde g\u00f6sterilmi\u015ftir. Bu \u00e7al\u0131\u015fma, Abdala’n\u0131n ger\u00e7ek d\u00fcnyadaki a\u015f\u0131 etkilili\u011fini (AE) tahmin etmeyi ama\u00e7lam\u0131\u015ft\u0131r.<\/p>\n

Havana’da ger\u00e7ekle\u015ftirilen retrospektif kohort \u00e7al\u0131\u015fmas\u0131nda, COVID-19’a ba\u011fl\u0131 ciddi hastal\u0131k ve \u00f6l\u00fcm\u00fc \u00f6nlemede (birincil sonu\u00e7lar) AE’yi de\u011ferlendirmek i\u00e7in K\u00fcba Halk Sa\u011fl\u0131\u011f\u0131 Bakanl\u0131\u011f\u0131 veritabanlar\u0131 (12 May\u0131s-31 A\u011fustos 2021) analiz edilmi\u015ftir. \u00c7al\u0131\u015fmaya 1.355.638 ki\u015fi dahil edilmi\u015ftir. \u015eiddetli hastal\u0131\u011fa kar\u015f\u0131 \u00f6ng\u00f6r\u00fclen AE, k\u0131smen a\u015f\u0131lanm\u0131\u015flarda %93.3 (%95 GA: 92 1-94 3), tam a\u015f\u0131lanm\u0131\u015flarda %98.2 (%95 GA: 97 9-98 5) bulunmu\u015ftur; \u00f6l\u00fcme kar\u015f\u0131 \u00f6ng\u00f6r\u00fclen AE ise k\u0131smen a\u015f\u0131lanm\u0131\u015flarda %94.1 (%95 CI: 92 5-95 4), tam a\u015f\u0131lanm\u0131\u015flarda %98.7 (%95 CI: 98 3-99 0) bulunmu\u015ftur. AE t\u00fcm ya\u015f gruplar\u0131nda %92’yi a\u015fm\u0131\u015ft\u0131r. \u00c7al\u0131\u015fma s\u00fcresince g\u00f6r\u00fclen g\u00fcnl\u00fck vakalar ve \u00f6l\u00fcmler, modellemelerle \u00f6ng\u00f6r\u00fcld\u00fc\u011f\u00fc gibi %90’\u0131n \u00fczerinde AE’ye kar\u015f\u0131l\u0131k gelmi\u015ftir.<\/p>\n

K\u00fcba Abdala protein alt birim a\u015f\u0131s\u0131n\u0131n, ger\u00e7ek ya\u015fam ko\u015fullar\u0131nda COVID-19’dan kaynaklanan ciddi hastal\u0131klar\u0131 ve \u00f6l\u00fcmleri \u00f6nlemede y\u00fcksek etkiye sahip oldu\u011fu sonucuna var\u0131lm\u0131\u015ft\u0131r.<\/p>\n

Makale \u0130\u00e7in T\u0131klay\u0131n\u0131z<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

K\u00fcba’n\u0131n pandemi s\u0131ras\u0131nda geli\u015ftirdi\u011fi Abdala a\u015f\u0131s\u0131n\u0131n COVID-19’dan kaynaklanan ciddi hastal\u0131klar\u0131 ve \u00f6l\u00fcmleri \u00f6nlemede y\u00fcksek etkiye sahip oldu\u011funu g\u00f6steren \u00e7al\u0131\u015fma 24 Eyl\u00fcl 2022’de The Lancet dergisinde yay\u0131mland\u0131. K\u00fcba protein alt birim a\u015f\u0131s\u0131 Abdala’n\u0131n, SARS-CoV-2’ye kar\u015f\u0131 g\u00fcvenli\u011fi, tolere edilebilirli\u011fi ve etkilili\u011fi (%92 3 [%95 GA: 85 7-95 8]) klinik deneylerde g\u00f6sterilmi\u015ftir. Bu \u00e7al\u0131\u015fma, Abdala’n\u0131n ger\u00e7ek d\u00fcnyadaki a\u015f\u0131 etkilili\u011fini (AE) tahmin etmeyi ama\u00e7lam\u0131\u015ft\u0131r. Havana’da ger\u00e7ekle\u015ftirilen retrospektif kohort \u00e7al\u0131\u015fmas\u0131nda, COVID-19’a ba\u011fl\u0131 ciddi hastal\u0131k ve \u00f6l\u00fcm\u00fc \u00f6nlemede (birincil sonu\u00e7lar) AE’yi de\u011ferlendirmek i\u00e7in K\u00fcba Halk Sa\u011fl\u0131\u011f\u0131 Bakanl\u0131\u011f\u0131 veritabanlar\u0131 (12 May\u0131s-31 A\u011fustos 2021) analiz edilmi\u015ftir. \u00c7al\u0131\u015fmaya 1.355.638 ki\u015fi dahil edilmi\u015ftir. \u015eiddetli hastal\u0131\u011fa kar\u015f\u0131 \u00f6ng\u00f6r\u00fclen AE, k\u0131smen a\u015f\u0131lanm\u0131\u015flarda […]<\/p>\n","protected":false},"author":4,"featured_media":6031,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6030"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=6030"}],"version-history":[{"count":2,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6030\/revisions"}],"predecessor-version":[{"id":6033,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/6030\/revisions\/6033"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/6031"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=6030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=6030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=6030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}