{"id":5996,"date":"2022-08-25T15:02:54","date_gmt":"2022-08-25T12:02:54","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=5996"},"modified":"2022-08-25T15:02:54","modified_gmt":"2022-08-25T12:02:54","slug":"covid-19-mrna-asilarinin-kalp-ve-dolasim-sisteminde-pihtilasma-yaptigi-iddialari-hakkinda-aciklama","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/covid-19-mrna-asilarinin-kalp-ve-dolasim-sisteminde-pihtilasma-yaptigi-iddialari-hakkinda-aciklama\/","title":{"rendered":"COVID-19 mRNA A\u015f\u0131lar\u0131n\u0131n Kalp ve Dola\u015f\u0131m Sisteminde P\u0131ht\u0131la\u015fma Yapt\u0131\u011f\u0131 \u0130ddialar\u0131 Hakk\u0131nda A\u00e7\u0131klama"},"content":{"rendered":"

Pandeminin t\u00fcm d\u00fcnyada h\u0131z\u0131n\u0131 kesmeden devam etmesi \u00f6zellikle a\u015f\u0131s\u0131 olmayan ve ek hastal\u0131klar\u0131 olan ki\u015filerde halen y\u00fcksek mortalite oranlar\u0131n\u0131n g\u00f6r\u00fclmesi bir halk sa\u011fl\u0131\u011f\u0131 sorunu olarak \u00f6nemini korumaktad\u0131r.<\/p>\n

COVID-19 i\u00e7in son iki y\u0131l i\u00e7erisinde kullan\u0131ma giren ve yayg\u0131n olarak kullan\u0131lan a\u015f\u0131lar i\u00e7erisinde, hastal\u0131\u011fa kar\u015f\u0131 koruma potansiyeli ve a\u011f\u0131r hastal\u0131\u011f\u0131 engelleme etkisi en y\u00fcksek olan a\u015f\u0131lar mRNA a\u015f\u0131lar\u0131d\u0131r. Bug\u00fcne kadar d\u00fcnya genelinde 5 milyar dozdan fazla uygulanm\u0131\u015f olan mRNA a\u015f\u0131lar\u0131 genel olarak \u00e7ok g\u00fcvenli kabul edilmektedir. A\u015f\u0131 yerinde a\u011fr\u0131, ate\u015f, kas a\u011fr\u0131s\u0131 gibi nispeten s\u0131k g\u00f6r\u00fclen yan etkileri olmakla birlikte bu yan etkiler k\u0131sa s\u00fcre i\u00e7inde kendili\u011finden d\u00fczelmektedir. Lenf bezlerinde \u015fi\u015flik ve gen\u00e7 erkeklerde kalp kas\u0131-kalp zar\u0131 iltihab\u0131 gibi nadir g\u00f6r\u00fclen yan etkiler de \u00e7o\u011funlukla tedavisiz ayaktan izlemle iyile\u015fmektedir.\u00a0 Bu durum hem faz \u00e7al\u0131\u015fmalar\u0131 hem de ard\u0131ndan yap\u0131lan pek \u00e7ok ger\u00e7ek ya\u015fam verisi sunan \u00e7al\u0131\u015fmayla kan\u0131tlanm\u0131\u015ft\u0131r.<\/p>\n

COVID-19 a\u015f\u0131 uygulamalar\u0131n\u0131n ba\u015flamas\u0131yla zaman zaman g\u00fcndeme getirilen ve son g\u00fcnlerde yaz\u0131l\u0131 ve g\u00f6rsel bas\u0131nda daha s\u0131k yer alan, mRNA a\u015f\u0131lar\u0131n\u0131n kalp krizi ba\u015fta olmak \u00fczere \u00e7e\u015fitli kalp-damar hastal\u0131klar\u0131n\u0131 art\u0131rd\u0131\u011f\u0131na, kalp ve dola\u015f\u0131m sisteminde p\u0131ht\u0131la\u015fmaya neden oldu\u011funa dair haberler bilimsel ger\u00e7ekli\u011fi yans\u0131tmaktan uzakt\u0131r. Geli\u015ftirilen her yeni a\u015f\u0131 gibi COVID-19 a\u015f\u0131lar\u0131nda da ger\u00e7ek ya\u015fam uygulamalar\u0131n\u0131n uzun s\u00fcreli takiplerinde faz \u00e7al\u0131\u015fmalar\u0131nda rastlanmayan nadir baz\u0131 yan etkiler saptanabilir. Fakat g\u00fcn\u00fcm\u00fcz literat\u00fcr bilgileri \u0131\u015f\u0131\u011f\u0131nda bu zamana kadar yap\u0131lan \u00e7al\u0131\u015fmalar ve 2 y\u0131la yakla\u015fan g\u00f6zlem s\u00fcresi de\u011ferlendirdi\u011finde mRNA a\u015f\u0131lar\u0131n\u0131n kalp damar sorunlar\u0131na (p\u0131ht\u0131la\u015fma, kalp krizi vb.) \u00a0neden oldu\u011funa dair bilimsel bir kan\u0131t ortaya \u00e7\u0131km\u0131\u015f de\u011fildir. Aksine kardiyolojik olarak riskli bireylerde COVID-19’un kendisinin a\u011f\u0131r seyir ve p\u0131ht\u0131la\u015fma gibi kalp damar sorunlar\u0131na neden oldu\u011fu \u00e7ok say\u0131da olgu bildirimi, g\u00f6zlemsel ve kar\u015f\u0131la\u015ft\u0131rmal\u0131 bilimsel \u00e7al\u0131\u015fma ile kan\u0131tlanm\u0131\u015f olup bu bireylerde a\u015f\u0131n\u0131n uygulanmas\u0131 riskleri azaltmaktad\u0131r.<\/p>\n

Nitekim i\u00e7inde bulundu\u011fumuz y\u0131l i\u00e7inde olduk\u00e7a \u00f6nemli dergilerde yay\u0131mlanan ve milyonlarca a\u015f\u0131 olmu\u015f-olmam\u0131\u015f ki\u015fideki sonu\u00e7lar\u0131 kar\u015f\u0131la\u015ft\u0131ran ara\u015ft\u0131rmalarda; mRNA a\u015f\u0131lar\u0131n\u0131n p\u0131ht\u0131la\u015fmaya neden olmad\u0131\u011f\u0131, \u00a0COVID-19 ge\u00e7irmenin bu y\u00f6nde \u00f6nemli bir risk olu\u015fturdu\u011fu saptanm\u0131\u015f, ayr\u0131ca COVID-19\u2019a kar\u015f\u0131 a\u015f\u0131lanman\u0131n kalp krizi ve fel\u00e7 (inme) s\u0131kl\u0131\u011f\u0131nda azalma ile ili\u015fkisi oldu\u011fu g\u00f6sterilmi\u015ftir (1,2,3).<\/p>\n

T\u00fcm bu veriler \u0131\u015f\u0131\u011f\u0131nda vatanda\u015flar\u0131m\u0131z\u0131 bilimsel otoriteleri takip etmeye, bireysel sa\u011fl\u0131klar\u0131, toplum sa\u011fl\u0131\u011f\u0131 ve pandeminin kontrol\u00fc i\u00e7in a\u015f\u0131 \u015femalar\u0131n\u0131 tamamlamaya, yetkilileri ise a\u015f\u0131 \u00a0konusunda net mesajlar vermeye, daha kararl\u0131 bir \u015fekilde ve etkili a\u015f\u0131lama \u00e7al\u0131\u015fmas\u0131 yapmaya \u00e7a\u011f\u0131r\u0131yoruz.<\/p>\n

Sayg\u0131lar\u0131m\u0131zla,<\/p>\n

KL\u0130M\u0130K EB\u00c7G Y\u00fcr\u00fctme Kurulu<\/strong><\/p>\n

Kaynaklar<\/strong><\/p>\n

    \n
  1. Xie, Y., Xu, E., Bowe, B., & Al-Aly, Z. (\u015eubat 2022). Long-term cardiovascular outcomes of COVID-19.\u00a0Nature medicine<\/em>,\u00a028<\/em>(3), 583-590.<\/li>\n
  2. Kim, Y. E., Huh, K., Park, Y. J., Peck, K. R., & Jung, J. (Temmuz 2022). Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection.\u00a0JAMA<\/em>. doi:10.1001\/jama.2022.12992.<\/li>\n
  3. Botton J, Jabagi MJ, Bertrand M et al. (A\u011fustos 2022). Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following COVID-19 Vaccines in Adults Younger Than 75 Years in France. Ann Intern Med.<\/em> https:\/\/doi.org\/10.7326\/M22-0988.<\/li>\n<\/ol>\n

     <\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Pandeminin t\u00fcm d\u00fcnyada h\u0131z\u0131n\u0131 kesmeden devam etmesi \u00f6zellikle a\u015f\u0131s\u0131 olmayan ve ek hastal\u0131klar\u0131 olan ki\u015filerde halen y\u00fcksek mortalite oranlar\u0131n\u0131n g\u00f6r\u00fclmesi bir halk sa\u011fl\u0131\u011f\u0131 sorunu olarak \u00f6nemini korumaktad\u0131r. COVID-19 i\u00e7in son iki y\u0131l i\u00e7erisinde kullan\u0131ma giren ve yayg\u0131n olarak kullan\u0131lan a\u015f\u0131lar i\u00e7erisinde, hastal\u0131\u011fa kar\u015f\u0131 koruma potansiyeli ve a\u011f\u0131r hastal\u0131\u011f\u0131 engelleme etkisi en y\u00fcksek olan a\u015f\u0131lar mRNA a\u015f\u0131lar\u0131d\u0131r. Bug\u00fcne kadar d\u00fcnya genelinde 5 milyar dozdan fazla uygulanm\u0131\u015f olan mRNA a\u015f\u0131lar\u0131 genel olarak \u00e7ok g\u00fcvenli kabul edilmektedir. A\u015f\u0131 yerinde a\u011fr\u0131, ate\u015f, kas a\u011fr\u0131s\u0131 gibi nispeten s\u0131k g\u00f6r\u00fclen yan etkileri olmakla birlikte bu yan etkiler k\u0131sa s\u00fcre i\u00e7inde kendili\u011finden d\u00fczelmektedir. Lenf bezlerinde \u015fi\u015flik ve […]<\/p>\n","protected":false},"author":4,"featured_media":5997,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5996"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=5996"}],"version-history":[{"count":1,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5996\/revisions"}],"predecessor-version":[{"id":5998,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5996\/revisions\/5998"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/5997"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=5996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=5996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=5996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}