{"id":5201,"date":"2021-11-11T16:02:58","date_gmt":"2021-11-11T13:02:58","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=5201"},"modified":"2021-11-11T16:02:58","modified_gmt":"2021-11-11T13:02:58","slug":"bagisikligi-baskilanmis-bir-covid-19-hastasinda-remdesivir-direnci","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/bagisikligi-baskilanmis-bir-covid-19-hastasinda-remdesivir-direnci\/","title":{"rendered":"Ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 Bask\u0131lanm\u0131\u015f Bir COVID-19 Hastas\u0131nda Remdesivir Direnci"},"content":{"rendered":"

\"\"medRxiv’de 9 Kas\u0131m 2021’de yay\u0131mlanan olgu sunumuna g\u00f6re, ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f bir hastan\u0131n COVID-19 tedavisinde remdesivir kullan\u0131lmas\u0131 sonucunda yeni ve diren\u00e7li bir mutasyonun ortaya \u00e7\u0131kt\u0131\u011f\u0131 saptand\u0131. Yale \u00dcniversitesi ve Washington \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar COVID-19 ge\u00e7iren ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f hastalarda remdesivir direncinin izlenmesinin \u00f6nemini ve kombinasyon tedavilerinin potansiyel faydas\u0131n\u0131 vurguluyorlar.<\/strong><\/p>\n

SARS-CoV-2’nin remdesivire diren\u00e7li mutasyonlar\u0131n\u0131n in vitro<\/em> deneylerde olu\u015ftu\u011fu, ancak antiviral bir ajan olan remdesivirle tedavi g\u00f6ren hastalarda \u015fimdiye kadar bildirilmemi\u015f oldu\u011fu belirtiliyor. \u00c7al\u0131\u015fmada, indolent ve uzun s\u00fcreli SARS-CoV-2 infeksiyonu seyri geli\u015ftiren ve edinilmi\u015f B-h\u00fccre eksikli\u011fi olan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f bir kad\u0131n hasta sunulmu\u015f. Remdesivir tedavisiyle hastan\u0131n semptomlar\u0131 hafiflemi\u015f ve ge\u00e7ici bir virolojik yan\u0131t elde edilmi\u015f, ancak y\u00fcksek dereceli viral sa\u00e7\u0131l\u0131m\u0131n n\u00fcksetmesiyle komplike hale gelmi\u015f. T\u00fcm genom diziliminde, nsp12 RNA’ya ba\u011f\u0131ml\u0131 RNA polimerazda tedavi \u00f6ncesi \u00f6rneklerde bulunmayan bir mutasyon olan E802D tan\u0131mlanm\u0131\u015f. In vitro<\/em> deneyler, mutasyonun remdesivir IC50’de ~6 kat art\u0131\u015f sa\u011flad\u0131\u011f\u0131n\u0131, ancak remdesivir olmad\u0131\u011f\u0131nda “uyum bedeli (fitness cost)” ile\u00a0 sonu\u00e7land\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015f. Hastada kal\u0131c\u0131 klinik ve virolojik yan\u0131t, casirivimab-imdevimab ile tedaviden sonra sa\u011flanm\u0131\u015f. In vitro<\/em> g\u00f6zlemlenen uyum bedeli E802D’nin olu\u015fturdu\u011fu riski s\u0131n\u0131rlayabilse de, \u00e7al\u0131\u015fma, SARS-CoV-2 infeksiyonu olan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f hastalarda remdesivir direncinin izlenmesinin \u00f6nemini ve kombinasyon tedavilerinin potansiyel faydas\u0131n\u0131 g\u00f6stermesi a\u00e7\u0131s\u0131ndan \u00f6nemli bulunmaktad\u0131r.<\/p>\n

Makale \u0130\u00e7in T\u0131klay\u0131n\u0131z<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

medRxiv’de 9 Kas\u0131m 2021’de yay\u0131mlanan olgu sunumuna g\u00f6re, ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f bir hastan\u0131n COVID-19 tedavisinde remdesivir kullan\u0131lmas\u0131 sonucunda yeni ve diren\u00e7li bir mutasyonun ortaya \u00e7\u0131kt\u0131\u011f\u0131 saptand\u0131. Yale \u00dcniversitesi ve Washington \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar COVID-19 ge\u00e7iren ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f hastalarda remdesivir direncinin izlenmesinin \u00f6nemini ve kombinasyon tedavilerinin potansiyel faydas\u0131n\u0131 vurguluyorlar. SARS-CoV-2’nin remdesivire diren\u00e7li mutasyonlar\u0131n\u0131n in vitro deneylerde olu\u015ftu\u011fu, ancak antiviral bir ajan olan remdesivirle tedavi g\u00f6ren hastalarda \u015fimdiye kadar bildirilmemi\u015f oldu\u011fu belirtiliyor. \u00c7al\u0131\u015fmada, indolent ve uzun s\u00fcreli SARS-CoV-2 infeksiyonu seyri geli\u015ftiren ve edinilmi\u015f B-h\u00fccre eksikli\u011fi olan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f bir kad\u0131n hasta sunulmu\u015f. Remdesivir tedavisiyle hastan\u0131n semptomlar\u0131 hafiflemi\u015f ve ge\u00e7ici bir virolojik yan\u0131t elde edilmi\u015f, […]<\/p>\n","protected":false},"author":4,"featured_media":5202,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5201"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=5201"}],"version-history":[{"count":1,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5201\/revisions"}],"predecessor-version":[{"id":5203,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/5201\/revisions\/5203"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/5202"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=5201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=5201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=5201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}