{"id":3881,"date":"2021-02-23T13:00:02","date_gmt":"2021-02-23T10:00:02","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=3881"},"modified":"2021-02-23T19:00:18","modified_gmt":"2021-02-23T16:00:18","slug":"arastirmacilar-siddetli-covid-19a-yol-acan-genetik-yatkinligi-ortaya-cikardi","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/arastirmacilar-siddetli-covid-19a-yol-acan-genetik-yatkinligi-ortaya-cikardi\/","title":{"rendered":"Ara\u015ft\u0131rmac\u0131lar \u015eiddetli COVID-19&#8217;a Yol A\u00e7an Genetik Yatk\u0131nl\u0131\u011f\u0131 Ortaya \u00c7\u0131kard\u0131"},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-45706 alignleft\" src=\"https:\/\/www.klimik.org.tr\/wp-content\/uploads\/2015\/12\/aurekalert.png\" alt=\"\" width=\"100\" height=\"27\" \/><strong>HSE \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, \u015fiddetli COVID-19&#8217;a yol a\u00e7an genetik yatk\u0131nl\u0131\u011f\u0131 ke\u015ffederek d\u00fcnyada bir ilke imza att\u0131lar. \u00c7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 Frontiers in Immunology dergisinde yay\u0131mland\u0131.<\/strong><\/p>\n<p>T h\u00fccre ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131, insan v\u00fccudunun viral infeksiyonlarla sava\u015fmak i\u00e7in kulland\u0131\u011f\u0131 kilit mekanizmalardan biridir. H\u00fccre ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 geli\u015fiminde zemini, infekte olmu\u015f h\u00fccrelerin y\u00fczeyinde virus peptitlerinin ortaya \u00e7\u0131kmas\u0131 olu\u015fturur. Bunu, infekte h\u00fccreleri \u00f6ld\u00fcrmeye ba\u015flayan T lenfositlerinin aktivasyonu izler. Virus peptitlerini ba\u015far\u0131yla sunma becerisi b\u00fcy\u00fck \u00f6l\u00e7\u00fcde genetik taraf\u0131ndan belirlenir. \u0130nsan h\u00fccrelerinde peptitlerin sunumdan insan l\u00f6kosit antijen s\u0131n\u0131f I (HLA-I) molek\u00fclleri sorumludur. Bu t\u00fcr alt\u0131 molek\u00fclden olu\u015fan set her insanda benzersizdir ve bireyin ebeveynlerinden miras al\u0131n\u0131r. Basit bir ifadeyle, alel seti virusu iyi tespit ederse ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri infekte olmu\u015f h\u00fccreleri h\u0131zl\u0131 bir \u015fekilde tespit edecek ve yok edecektir. Ki\u015finin sahip oldu\u011fu set b\u00f6yle bir tespitte k\u00f6t\u00fcyse daha ciddi hastal\u0131k g\u00f6r\u00fclme olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir.<\/p>\n<p><a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2021-02\/nruh-rrg021821.php\"><strong>Haber \u0130\u00e7in T\u0131klay\u0131n\u0131z<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HSE \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, \u015fiddetli COVID-19&#8217;a yol a\u00e7an genetik yatk\u0131nl\u0131\u011f\u0131 ke\u015ffederek d\u00fcnyada bir ilke imza att\u0131lar. \u00c7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 Frontiers in Immunology dergisinde yay\u0131mland\u0131. T h\u00fccre ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131, insan v\u00fccudunun viral infeksiyonlarla sava\u015fmak i\u00e7in kulland\u0131\u011f\u0131 kilit mekanizmalardan biridir. H\u00fccre ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 geli\u015fiminde zemini, infekte olmu\u015f h\u00fccrelerin y\u00fczeyinde virus peptitlerinin ortaya \u00e7\u0131kmas\u0131 olu\u015fturur. Bunu, infekte h\u00fccreleri \u00f6ld\u00fcrmeye ba\u015flayan T lenfositlerinin aktivasyonu izler. Virus peptitlerini ba\u015far\u0131yla sunma becerisi b\u00fcy\u00fck \u00f6l\u00e7\u00fcde genetik taraf\u0131ndan belirlenir. \u0130nsan h\u00fccrelerinde peptitlerin sunumdan insan l\u00f6kosit antijen s\u0131n\u0131f I (HLA-I) molek\u00fclleri sorumludur. Bu t\u00fcr alt\u0131 molek\u00fclden olu\u015fan set her insanda benzersizdir ve bireyin ebeveynlerinden miras al\u0131n\u0131r. Basit bir ifadeyle, alel seti virusu iyi [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":3882,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/3881"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=3881"}],"version-history":[{"count":1,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/3881\/revisions"}],"predecessor-version":[{"id":3883,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/3881\/revisions\/3883"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/3882"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=3881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=3881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=3881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}