{"id":2819,"date":"2020-09-21T20:32:38","date_gmt":"2020-09-21T17:32:38","guid":{"rendered":"https:\/\/www.klimik.org.tr\/koronavirus\/?p=2819"},"modified":"2020-09-22T11:43:26","modified_gmt":"2020-09-22T08:43:26","slug":"klimik-dernegi-covid-19-tedavisinde-kullanilmakta-olan-antiviral-ilaclarla-ilgili-bilimsel-gorus-yayimladi","status":"publish","type":"post","link":"https:\/\/www.klimik.org.tr\/koronavirus\/klimik-dernegi-covid-19-tedavisinde-kullanilmakta-olan-antiviral-ilaclarla-ilgili-bilimsel-gorus-yayimladi\/","title":{"rendered":"Klimik Derne\u011fi COVID-19 Tedavisinde Kullan\u0131lmakta Olan Antiviral \u0130la\u00e7larla \u0130lgili Bilimsel G\u00f6r\u00fc\u015f Yay\u0131mlad\u0131"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\">Klimik Derne\u011fi, t\u00fcm d\u00fcnyada COVID-19 tedavisinde yayg\u0131n olarak kullan\u0131lan ila\u00e7lar\u0131n ba\u015f\u0131nda gelen hidroksiklorokin, favipiravir, remdesivir ve lopinavir-ritonavirin tedavideki etkinli\u011fi ve g\u00fcvenilirli\u011fine ili\u015fkin, bug\u00fcne (20 Eyl\u00fcl 2020) kadar yay\u0131mlanm\u0131\u015f bilimsel \u00e7al\u0131\u015fmalar\u0131 analiz ederek, detayl\u0131 bir de\u011ferlendirme haz\u0131rlad\u0131. A\u015fa\u011f\u0131da \u00f6zetini okuyabilece\u011finiz g\u00f6r\u00fc\u015flerin bilimsel dayanaklar\u0131n\u0131 i\u00e7eren ayr\u0131nt\u0131l\u0131 de\u011ferlendirme yaz\u0131s\u0131n\u0131 <strong><a href=\"https:\/\/www.klimik.org.tr\/koronavirus\/covid-19-tedavisinde-kullanilmakta-olan-antiviral-ilaclar\/\">https:\/\/www.klimik.org.tr\/koronavirus\/covid-19-tedavisinde-kullanilmakta-olan-antiviral-ilaclar\/<\/a><\/strong>\u00a0adresinde bulabilirsiniz.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12pt; color: #000000;\"><strong>T\u00fcrk Klinik Mikrobiyoloji ve \u0130nfeksiyon Hastal\u0131klar\u0131 Derne\u011fi\u2019nin COVID-19 Tedavisinde Kullan\u0131lmakta Olan Antiviral \u0130la\u00e7larla \u0130lgili Bilimsel G\u00f6r\u00fc\u015f\u00fc<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #800000;\"><strong>Hidroksiklorokin:<\/strong><\/span> G\u00fcncel in vitro\/in vivo ve randomize kontroll\u00fc klinik \u00e7al\u0131\u015fmalar, ayaktan veya yatan, hafif\/orta\/a\u011f\u0131r seyirli COVID-19 olgular\u0131n\u0131n tedavisinde hidroksiklorokinin etkili olmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. <strong><em>Hidroksiklorokin, aksini bildiren yeni randomize kontroll\u00fc klinik \u00e7al\u0131\u015fma sonu\u00e7lar\u0131 olmad\u0131k\u00e7a COVID-19\u2019un asemptomatik, hafif, orta, a\u011f\u0131r formlar\u0131n\u0131n tedavisinde veya profilaksisinde kullan\u0131lmamal\u0131d\u0131r.<\/em><\/strong>\u00a0 Hidroksiklorokin, \u00f6zellikle QT\u2019yi uzatan azitromisin gibi di\u011fer ila\u00e7larla birlikte kullan\u0131ld\u0131\u011f\u0131nda hayat\u0131 tehdit edebilecek kardiyotoksik istenmeyen etkilere neden olabilir. \u00a0\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #800000;\"><strong>Favipiravir:<\/strong><\/span> COVID-19 tedavisinde Favipiravirin etkisini ara\u015ft\u0131ran az say\u0131da hasta i\u00e7eren \u00fc\u00e7 randomize kontroll\u00fc klinik \u00e7al\u0131\u015fmada, bu ajan\u0131n viral klirense ve\/veya baz\u0131 klinik sonu\u00e7lara olumlu etkilerinin olabilece\u011fi bildirilmi\u015ftir. Bu nedenle, <strong><em>favipiravirin \u00f6zellikle pn\u00f6monili ve\/veya riskli COVID-19 olgular\u0131n\u0131n tedavisinde kullan\u0131labilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.<\/em><\/strong> Ancak devam etmekte olan randomize kontroll\u00fc klinik \u00e7al\u0131\u015fmalar\u0131n sonu\u00e7lar\u0131 yak\u0131ndan izlenmeli, optimal dozunun ve tedavi s\u00fcresinin belirlenebilmesi i\u00e7in in vitro ve ek klinik \u00e7al\u0131\u015fmalar yap\u0131lmal\u0131d\u0131r.\u00a0\u00a0 Favipiravirin COVID-19 tedavisinde veya di\u011fer indikasyonlarla kullan\u0131m\u0131 s\u0131ras\u0131nda ciddi istenmeyen etkileri tan\u0131mlanmam\u0131\u015ft\u0131r.<\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #800000;\"><strong>Remdesivir:<\/strong> <\/span>SARS-CoV-2\u2019ye kar\u015f\u0131 in vitro ve in vivo hayvan deneylerinde etkili bulunan remdesivirin 1647 COVID-19 hastas\u0131n\u0131 i\u00e7eren iki randomize kontroll\u00fc \u00e7al\u0131\u015fmada klinik sonu\u00e7lara baz\u0131 olumlu etkileri oldu\u011fu g\u00f6sterilmi\u015ftir. Bu nedenlerle <strong><em>remdesivirin orta\/a\u011f\u0131r seyirli COVID-19 pn\u00f6monilerinde kullan\u0131labilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.<\/em><\/strong> Yeni klinik \u00e7al\u0131\u015fma sonu\u00e7lar\u0131na g\u00f6re kullan\u0131m indikasyonlar\u0131 tekrar de\u011ferlendirilmelidir. Remdesivirin COVID-19 tedavisinde kullan\u0131m\u0131 s\u0131ras\u0131nda geli\u015fen ciddi istenmeyen etki bildirilmemi\u015ftir.<\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #800000;\"><strong>Lopinavir\/Ritonavir:<\/strong><\/span> COVID-19 tedavisinde lopinavir\/ritonavirin etkinli\u011fini ara\u015ft\u0131ran az say\u0131daki randomize kontroll\u00fc \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 birbiriyle uyumsuzdur, 86 hasta i\u00e7eren bir randomize kontroll\u00fc \u00e7al\u0131\u015fmada bu ajan\u0131n etkisiz oldu\u011fu, 199 hasta i\u00e7eren bir randomize kontroll\u00fc \u00e7al\u0131\u015fmada belirgin olmasa da baz\u0131 olumlu etkilerinin olabilece\u011fi, birinde ise ribavirin ve interferonla kombine kullan\u0131lmas\u0131 halinde olumlu etkilerinin oldu\u011fu bildirilmi\u015ftir. Bu klinik \u00e7al\u0131\u015fmalar\u0131n genellikle az olgu say\u0131l\u0131 ve plasebo kontroll\u00fc olmamas\u0131ndan hareketle ek \u00e7al\u0131\u015fmalar\u0131n gerekli oldu\u011fu d\u00fc\u015f\u00fcn\u00fclmektedir.\u00a0 Lopinavir\/ritonavirin SARS-CoV-2 \u00fczerine etkisini ara\u015ft\u0131ran in vitro \u00e7al\u0131\u015fma say\u0131s\u0131 azd\u0131r, sonu\u00e7lar yetersizdir, ek \u00e7al\u0131\u015fmalar gereklidir. <strong><em>Di\u011fer ila\u00e7lar\u0131n olas\u0131 yan etkiler nedeniyle kullan\u0131lamad\u0131\u011f\u0131 orta a\u011f\u0131r seyirli COVID-19 ge\u00e7irmekte olan gebe hastalarda lopinavir\/ritonavir bir se\u00e7enek olabilir.<\/em><\/strong> Lopinavir\/ritonavirin COVID-19 tedavisinde, \u00f6zellikle kombinasyon rejiminin bir par\u00e7as\u0131 olarak klinik \u00e7al\u0131\u015fmalar i\u00e7inde yer alacak \u015fekilde kullan\u0131lmas\u0131 d\u00fc\u015f\u00fcn\u00fclebilir.<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">Salg\u0131n\u0131n ba\u015flamas\u0131n\u0131n \u00fczerinden sekiz ay ge\u00e7mi\u015f olmas\u0131na ra\u011fmen halen COVID-19&#8217;a kar\u015f\u0131 etkili oldu\u011fu kesin olarak g\u00f6sterilmi\u015f bir antiviral tedavi yoktur. COVID-19\u2019a etkili bir antiviral bulmak amac\u0131yla yap\u0131lan klinik \u00e7al\u0131\u015fmalarda en \u00e7ok incelenen ve tedavide yeniden konumland\u0131r\u0131larak (repurposing) kullan\u0131lan ajanlar, etkili tedavi bulunmas\u0131 konusunda zaman kayb\u0131na neden olmu\u015f olabilir.\u00a0 SARS-CoV-2\u2019ye \u00f6zg\u00fc yeni antivirallere acilen gereksinim vard\u0131r, mevcut kaynaklar\u0131n yeni ajanlar\u0131n ara\u015ft\u0131r\u0131lmas\u0131na, geli\u015ftirilmesine ve \u00e7al\u0131\u015f\u0131lmas\u0131na ayr\u0131lmas\u0131 en ak\u0131lc\u0131 yakla\u015f\u0131m olacakt\u0131r.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-2831 \" src=\"https:\/\/www.klimik.org.tr\/koronavirus\/wp-content\/uploads\/2020\/09\/klimik.logo_.amblem_V2_logo.png\" alt=\"\" width=\"587\" height=\"41\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Klimik Derne\u011fi, t\u00fcm d\u00fcnyada COVID-19 tedavisinde yayg\u0131n olarak kullan\u0131lan ila\u00e7lar\u0131n ba\u015f\u0131nda gelen hidroksiklorokin, favipiravir, remdesivir ve lopinavir-ritonavirin tedavideki etkinli\u011fi ve g\u00fcvenilirli\u011fine ili\u015fkin, bug\u00fcne (20 Eyl\u00fcl 2020) kadar yay\u0131mlanm\u0131\u015f bilimsel \u00e7al\u0131\u015fmalar\u0131 analiz ederek, detayl\u0131 bir de\u011ferlendirme haz\u0131rlad\u0131. A\u015fa\u011f\u0131da \u00f6zetini okuyabilece\u011finiz g\u00f6r\u00fc\u015flerin bilimsel dayanaklar\u0131n\u0131 i\u00e7eren ayr\u0131nt\u0131l\u0131 de\u011ferlendirme yaz\u0131s\u0131n\u0131 https:\/\/www.klimik.org.tr\/koronavirus\/covid-19-tedavisinde-kullanilmakta-olan-antiviral-ilaclar\/\u00a0adresinde bulabilirsiniz. &nbsp; T\u00fcrk Klinik Mikrobiyoloji ve \u0130nfeksiyon Hastal\u0131klar\u0131 Derne\u011fi\u2019nin COVID-19 Tedavisinde Kullan\u0131lmakta Olan Antiviral \u0130la\u00e7larla \u0130lgili Bilimsel G\u00f6r\u00fc\u015f\u00fc Hidroksiklorokin: G\u00fcncel in vitro\/in vivo ve randomize kontroll\u00fc klinik \u00e7al\u0131\u015fmalar, ayaktan veya yatan, hafif\/orta\/a\u011f\u0131r seyirli COVID-19 olgular\u0131n\u0131n tedavisinde hidroksiklorokinin etkili olmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Hidroksiklorokin, aksini bildiren yeni randomize kontroll\u00fc klinik \u00e7al\u0131\u015fma sonu\u00e7lar\u0131 olmad\u0131k\u00e7a COVID-19\u2019un asemptomatik, hafif, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":2820,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/2819"}],"collection":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/comments?post=2819"}],"version-history":[{"count":9,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/2819\/revisions"}],"predecessor-version":[{"id":2833,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/posts\/2819\/revisions\/2833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media\/2820"}],"wp:attachment":[{"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/media?parent=2819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/categories?post=2819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimik.org.tr\/koronavirus\/wp-json\/wp\/v2\/tags?post=2819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}